Pathogenic PS1 phosphorylation at Ser367

The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ‘dephosphorylated’ states. However, the functional outcome of...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Maesako, Masato, Horlacher, Jana, Zoltowska, Katarzyna M, Kastanenka, Ksenia V, Kara, Eleanna, Svirsky, Sarah, Keller, Laura J, Li, Xuejing, Hyman, Bradley T, Bacskai, Brian J, Berezovska, Oksana
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279945/
https://ncbi.nlm.nih.gov/pubmed/28132667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19720
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