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Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

The vitamin B(12) analog hydroxy-cobalamin[c-lactam] (HCCL) impairs hepatic mitochondrial protein synthesis and function of the electron transport chain in rats. We aimed to establish an in vivo model for mitochondrial dysfunction in mice, which could be used to investigate hepatotoxicity of mitocho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Haegler, Patrizia, Grünig, David, Berger, Benjamin, Terracciano, Luigi, Krähenbühl, Stephan, Bouitbir, Jamal
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279765/
https://ncbi.nlm.nih.gov/pubmed/28135329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171026
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