Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria.

Treatment of rats with the vitamin B12 analogue hydroxy-cobalamin[c-lactam] (HCCL) impairs methylmalonyl-CoA mutase function and leads to methylmalonic aciduria due to intracellular accumulation of propionyl and methylmalonyl-CoA. Since accumulation of these acyl-CoAs disrupts normal cellular regula...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Krahenbuhl, S, Ray, D B, Stabler, S P, Allen, R H, Brass, E P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329844/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1701451/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114942
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