Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency

During B and T lymphocyte maturation, V(D)J recombination is initiated by creation of DNA double-strand breaks. Artemis is an exonuclease essential for their subsequent repair by nonhomologous end-joining. Mutations in DCLRE1C, the gene encoding Artemis, cause T(−)B(−)NK(+) severe combined immunodef...

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Publicat a:Hum Gene Ther
Autors principals: Punwani, Divya, Kawahara, Misako, Yu, Jason, Sanford, Ukina, Roy, Sushmita, Patel, Kiran, Carbonaro, Denise A., Karlen, Andrea D., Khan, Sara, Cornetta, Kenneth, Rothe, Michael, Schambach, Axel, Kohn, Donald B., Malech, Harry L., McIvor, R. Scott, Puck, Jennifer M., Cowan, Morton J.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278830/
https://ncbi.nlm.nih.gov/pubmed/27611239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.064
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