Characterization of the Human Artemis Promoter by Heterologous Gene Expression In Vitro and In Vivo

Artemis is an endonucleolytic enzyme involved in nonhomologous double-strand break repair and V(D)J recombination. Deficiency of Artemis results in a B(−) T(−) radiosensitive severe combined immunodeficiency, which may potentially be treatable by Artemis gene transfer into hematopoietic stem cells....

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Main Authors: Multhaup, Megan M., Gurram, Sweta, Podetz-Pedersen, Kelly M., Karlen, Andrea D., Swanson, Debra L., Somia, Nikunj V., Hackett, Perry B., Cowan, Morton J., McIvor, R. Scott
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2011
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Original Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183654/
https://ncbi.nlm.nih.gov/pubmed/21663454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2011.1244
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