Cytotoxicity Associated with Artemis Overexpression After Lentiviral Vector-Mediated Gene Transfer

Artemis is a hairpin-opening endonuclease involved in nonhomologous end-joining and V(D)J recombination. Deficiency of Artemis results in radiation-sensitive severe combined immunodeficiency (SCID) characterized by complete absence of T and B cells due to an arrest at the receptor recombination stag...

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Bibliographic Details
Main Authors: Multhaup, Megan, Karlen, Andrea D., Swanson, Debra L., Wilber, Andrew, Somia, Nikunj V., Cowan, Morton J., McIvor, R. Scott
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938362/
https://ncbi.nlm.nih.gov/pubmed/20163250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.162
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