Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and as yet unresolved, question is whether the mucosal bottleneck selects for viruses with increased transmission fitness. Here, we characterize...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Iyer, Shilpa S., Bibollet-Ruche, Frederic, Sherrill-Mix, Scott, Learn, Gerald H., Plenderleith, Lindsey, Smith, Andrew G., Barbian, Hannah J., Russell, Ronnie M., Gondim, Marcos V. P., Bahari, Catherine Y., Shaw, Christiana M., Li, Yingying, Decker, Timothy, Haynes, Barton F., Shaw, George M., Sharp, Paul M., Borrow, Persephone, Hahn, Beatrice H.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278458/
https://ncbi.nlm.nih.gov/pubmed/28069935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620144114
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