Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

Epigenetic silencing of fragile X mental retardation 1 (FMR1) causes fragile X syndrome (FXS), a common inherited form of intellectual disability and autism. FXS correlates with abnormal synapse and dendritic spine development, but the molecular link between the absence of the FMR1 product FMRP, an...

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Publicado en:Sci Signal
Autores principales: Kashima, Risa, Roy, Sougata, Ascano, Manuel, Martinez-Cerdeno, Veronica, Ariza-Torres, Jeanelle, Kim, Sunghwan, Louie, Justin, Lu, Yao, Leyton, Patricio, Bloch, Kenneth D., Kornberg, Thomas B., Hagerman, Paul J., Hagerman, Randi, Lagna, Giorgio, Hata, Akiko
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5274719/
https://ncbi.nlm.nih.gov/pubmed/27273096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf6060
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