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Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity
Current strategies for HIV-1 eradication require the reactivation of latent HIV-1 in resting CD4(+) T cells (rCD4s). Global T cell activation is a well-characterized means of inducing HIV-1 transcription, but is considered too toxic for clinical applications. Here, we have explored a strategy that i...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Clin Invest |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5272184/ https://ncbi.nlm.nih.gov/pubmed/28094770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89552 |
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