Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis

The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic glucose production (HGP), and hepatic ketog...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Perry, Rachel J., Peng, Liang, Abulizi, Abudukadier, Kennedy, Lynn, Cline, Gary W., Shulman, Gerald I.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272181/
https://ncbi.nlm.nih.gov/pubmed/28112679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88477
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