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Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis
The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic glucose production (HGP), and hepatic ketog...
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| Veröffentlicht in: | J Clin Invest |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5272181/ https://ncbi.nlm.nih.gov/pubmed/28112679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88477 |
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