FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

OBJECTIVE: To validate new mitochondrial myopathy serum biomarkers for diagnostic use. METHODS: We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) mitochondrial diseases and (2) nonmitochondrial disorders partially overlapping with mitochondrial disorder phenotypes. We (3) did a meta...

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Publicat a:Neurology
Autors principals: Lehtonen, Jenni M., Forsström, Saara, Bottani, Emanuela, Viscomi, Carlo, Baris, Olivier R., Isoniemi, Helena, Höckerstedt, Krister, Österlund, Pia, Hurme, Mikko, Jylhävä, Juulia, Leppä, Sirpa, Markkula, Ritva, Heliö, Tiina, Mombelli, Giuliana, Uusimaa, Johanna, Laaksonen, Reijo, Laaksovirta, Hannu, Auranen, Mari, Zeviani, Massimo, Smeitink, Jan, Wiesner, Rudolf J., Nakada, Kazuto, Isohanni, Pirjo, Suomalainen, Anu
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270510/
https://ncbi.nlm.nih.gov/pubmed/27794108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003374
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