FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

OBJECTIVE: To validate new mitochondrial myopathy serum biomarkers for diagnostic use. METHODS: We analyzed serum FGF21 (S-FGF21) and GDF15 from patients with (1) mitochondrial diseases and (2) nonmitochondrial disorders partially overlapping with mitochondrial disorder phenotypes. We (3) did a meta...

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Publicado no:Neurology
Main Authors: Lehtonen, Jenni M., Forsström, Saara, Bottani, Emanuela, Viscomi, Carlo, Baris, Olivier R., Isoniemi, Helena, Höckerstedt, Krister, Österlund, Pia, Hurme, Mikko, Jylhävä, Juulia, Leppä, Sirpa, Markkula, Ritva, Heliö, Tiina, Mombelli, Giuliana, Uusimaa, Johanna, Laaksonen, Reijo, Laaksovirta, Hannu, Auranen, Mari, Zeviani, Massimo, Smeitink, Jan, Wiesner, Rudolf J., Nakada, Kazuto, Isohanni, Pirjo, Suomalainen, Anu
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270510/
https://ncbi.nlm.nih.gov/pubmed/27794108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003374
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