Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

BACKGROUND: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. RESULTS: We apply a novel analytical approach to measure and compare transcriptional and epigenetic vari...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Ecker, Simone, Chen, Lu, Pancaldi, Vera, Bagger, Frederik O., Fernández, José María, Carrillo de Santa Pau, Enrique, Juan, David, Mann, Alice L., Watt, Stephen, Casale, Francesco Paolo, Sidiropoulos, Nikos, Rapin, Nicolas, Merkel, Angelika, Stunnenberg, Hendrik G., Stegle, Oliver, Frontini, Mattia, Downes, Kate, Pastinen, Tomi, Kuijpers, Taco W., Rico, Daniel, Valencia, Alfonso, Beck, Stephan, Soranzo, Nicole, Paul, Dirk S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270224/
https://ncbi.nlm.nih.gov/pubmed/28126036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1156-8
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