A Multi-Network Approach Identifies Protein-specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

Here we report proteomic analyses of 129 human cortical tissues to define changes associated with asymptomatic and symptomatic stages of Alzheimer’s Disease (AD). Network analysis revealed 16 modules of co-expressed proteins, 10 of which correlated with AD phenotypes. A subset of modules overlapped...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Seyfried, Nicholas T., Dammer, Eric B., Swarup, Vivek, Nandakumar, Divya, Duong, Duc M., Yin, Luming, Deng, Qiudong, Nguyen, Tram, Hales, Chadwick M., Wingo, Thomas, Glass, Jonathan, Gearing, Marla, Thambisetty, Madhav, Troncoso, Juan C., Geschwind, Daniel H., Lah, James J., Levey, Allan I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269514/
https://ncbi.nlm.nih.gov/pubmed/27989508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.11.006
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