Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications

Recent hemophilia B clinical trials using adeno-associated virus (AAV) gene delivery have demonstrated much lower FIX production in patients compared to the high levels observed in animal models and AAV capsid specific CTLs response elicited at high doses of AAV vectors. These results emphasize the...

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Bibliografske podrobnosti
izdano v:Gene Ther
Main Authors: Wang, Mei, Sun, Junjiang, Crosby, Ashley, Woodard, Kenton, Hirsch, Matthew L., Samulski, R. Jude, Li, Chengwen
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269444/
https://ncbi.nlm.nih.gov/pubmed/27834949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.75
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