Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe (18)F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma

OBJECTIVES: Aerobic glycolysis, the main pathway of energy production in tumors (Warburg effect) allows detection of tumors by positron emission tomography (PET) using (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG). Since ionizing radiation (IR) is reported to switch aerobic glycolysis to mitochondrial...

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Udgivet i:PLoS One
Main Authors: Murayama, Chieko, Kawaguchi, Akira T., Kamijo, Akemi, Naito, Katsuko, Kanazawa, Masakatsu, Tsukada, Hideo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268465/
https://ncbi.nlm.nih.gov/pubmed/28125711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170911
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