Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with (18)F-BCPP-BF

BACKGROUND: In the present study, 2-tert-butyl-4-chloro-5-[6-(4-(18)F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one ((18)F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a useful biomarker for detecting acetaminophen-induced dysfunctions in the...

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Bibliografiske detaljer
Udgivet i:EJNMMI Res
Main Authors: Ohba, Hiroyuki, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Tsukada, Hideo
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118230/
https://ncbi.nlm.nih.gov/pubmed/27873239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0241-4
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