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Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice
OBJECTIVE: In humans, apolipoprotein (apo) E4 is associated with elevated plasma cholesterol levels and a high risk of developing atherosclerosis, whereas apoE2 is protective. Here we investigate the mechanism by which mice expressing human apoE isoforms recapitulate this association when they also...
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| Publicado en: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5268126/ https://ncbi.nlm.nih.gov/pubmed/18369154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.164863 |
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