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Distinct Brca1 mutations differentially reduce hematopoietic stem cell function
BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity from chemotherapy than those with BRCA2 mutati...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5267932/ https://ncbi.nlm.nih.gov/pubmed/28122244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.075 |
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