Efficacy and Immunogenicity of Unmodified and Pseudouridine-Modified mRNA Delivered Systemically with Lipid Nanoparticles in Vivo

mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity. Replacement of uridine bases with pseudouridine has been postulated to modulate both mRNA immunogenicity and potency. Here, we explore the immune re...

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Bibliografski detalji
Izdano u:Biomaterials
Glavni autori: Kauffman, Kevin J., Mir, Faryal F., Jhunjhunwala, Siddharth, Kaczmarek, James C., Hurtado, Juan E., Yang, Jung H., Webber, Matthew J., Kowalski, Piotr S., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5267554/
https://ncbi.nlm.nih.gov/pubmed/27680591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.09.006
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