Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcripti...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Majoros, Andrea, Platanitis, Ekaterini, Kernbauer-Hölzl, Elisabeth, Rosebrock, Felix, Müller, Mathias, Decker, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266721/
https://ncbi.nlm.nih.gov/pubmed/28184222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00029
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