Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcripti...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Majoros, Andrea, Platanitis, Ekaterini, Kernbauer-Hölzl, Elisabeth, Rosebrock, Felix, Müller, Mathias, Decker, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266721/
https://ncbi.nlm.nih.gov/pubmed/28184222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00029
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