Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16(INK4a) Expression in Subjects on Combination Therapy

BACKGROUND: HIV may amplify immunologic, physiologic, and functional changes of aging. We determined associations of frailty phenotype, a T-cell senescence marker (p16(INK4a) expression), age, and demographics with exposures of the intracellular metabolites (IM) and endogenous nucleotides (EN) of te...

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Publicat a:Antivir Ther
Autors principals: Dumond, Julie B., Francis, Owen, Cottrell, Mackenzie, Trezza, Christine, Prince, Heather M.A., Mollan, Katie, Sykes, Craig, Torrice, Chad, White, Nicole, Malone, Stephanie, Wang, Ruili, Van Dam, Cornelius, Patterson, Kristine B., Hudgens, Michael G., Sharpless, Norman E., Forrest, Alan
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266614/
https://ncbi.nlm.nih.gov/pubmed/26731175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP3017
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