Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers

Unbound drug is the pharmacodynamically relevant concentration. This study aimed to determine if chronologic age or markers of biologic aging, such as the frailty phenotype and p16(INK4a) gene expression, altered unbound pharmacokinetics (PKs) of efavirenz (EFV) and atazanavir/ritonavir (ATV/RTV). S...

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Enregistré dans:
Détails bibliographiques
Publié dans:CPT Pharmacometrics Syst Pharmacol
Auteurs principaux: Dumond, JB, Chen, J, Cottrell, M, Trezza, CR, Prince, HMA, Sykes, C, Torrice, C, White, N, Malone, S, Wang, R, Patterson, KB, Sharpless, NE, Forrest, A
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321807/
https://ncbi.nlm.nih.gov/pubmed/28032946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12151
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