Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16(INK4a) or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

OBJECTIVES: As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16(INK4a) expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of end...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maas, Brian M., Francis, Owen, Mollan, Katie R., Lee, Cynthia, Cottrell, Mackenzie L., Prince, Heather M. A., Sykes, Craig, Trezza, Christine, Torrice, Chad, White, Nicole, Malone, Stephanie, Hudgens, Michael G., Sharpless, Norman E., Dumond, Julie B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201235/
https://ncbi.nlm.nih.gov/pubmed/28036343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168709
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