The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2

INTRODUCTION: Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's...

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Publicat a:Alzheimers Dement (Amst)
Autors principals: Gispert, Juan Domingo, Monté, Gemma C., Suárez-Calvet, Marc, Falcon, Carles, Tucholka, Alan, Rojas, Santiago, Rami, Lorena, Sánchez-Valle, Raquel, Lladó, Albert, Kleinberger, Gernot, Haass, Christian, Molinuevo, José Luis
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
PART II. State of the Field: Advances in Neuroimaging from the 2016 Alzheimer's Imaging Consortium
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266482/
https://ncbi.nlm.nih.gov/pubmed/28149943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2016.12.002
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