Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury

Emerging evidence supports a role for innate immunity and microglia in Alzheimer’s disease (AD) pathophysiology. However, no marker related to microglia has been included in the temporal evolution models of AD. TREM2 is a transmembrane protein involved in innate immunity and is selectively expressed...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Suárez-Calvet, Marc, Caballero, Miguel Ángel Araque, Kleinberger, Gernot, Bateman, Randall J., Fagan, Anne M., Morris, John C., Levin, Johannes, Danek, Adrian, Ewers, Michael, Haass, Christian
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385711/
https://ncbi.nlm.nih.gov/pubmed/27974666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1767
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