CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether PGRN expression is changed in a disease severity‐specific manner in AD. We measured PGRN in cerebrospinal fluid (...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Suárez‐Calvet, Marc, Capell, Anja, Araque Caballero, Miguel Ángel, Morenas‐Rodríguez, Estrella, Fellerer, Katrin, Franzmeier, Nicolai, Kleinberger, Gernot, Eren, Erden, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M, Cruchaga, Carlos, Paumier, Katrina, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Jucker, Mathias, Masters, Colin L, Rossor, Martin N, Ringman, John M, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael, Ewers, Michael, Haass, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284390/
https://ncbi.nlm.nih.gov/pubmed/30482868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809712
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