HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

Tumor necrosis factor (TNF) is a key cytokine in HIV replication and pathogenesis. For reasons that are not entirely clear, the cytokine remains upregulated despite anti-retroviral therapy (ART). Here we demonstrate that HIV Nef induces an alternative TNF secretion mechanism that remains active in c...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ostalecki, Christian, Wittki, Sebastian, Lee, Jung-Hyun, Geist, Miriam M., Tibroni, Nadine, Harrer, Thomas, Schuler, Gerold, Fackler, Oliver T., Baur, Andreas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264432/
https://ncbi.nlm.nih.gov/pubmed/27773542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.027
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