HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

Antiretroviral therapy (ART) efficiently suppresses HIV replication but immune activation and low CD4 T cell counts often persist. The underlying mechanism of this ART-resistant pathogenesis is not clear. We observed that levels of plasma extracellular vesicles (pEV) are strongly elevated in HIV inf...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Lee, Jung-Hyun, Schierer, Stephan, Blume, Katja, Dindorf, Jochen, Wittki, Sebastian, Xiang, Wei, Ostalecki, Christian, Koliha, Nina, Wild, Stefan, Schuler, Gerold, Fackler, Oliver T., Saksela, Kalle, Harrer, Thomas, Baur, Andreas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856776/
https://ncbi.nlm.nih.gov/pubmed/27211553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.03.004
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