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Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4(+ )T lymphocytes in human lymphoid tissue ex vivo
BACKGROUND: HIV-1 Nef critically contributes to AIDS in part by augmenting virus titers in infected individuals. Analyzing which of Nef's activities contribute to HIV pathogenesis has been hampered by the lack of a cell culture model in which Nef exerts pronounced effects on HIV replication. Th...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630989/ https://ncbi.nlm.nih.gov/pubmed/19146681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-6 |
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