Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4(+ )T lymphocytes in human lymphoid tissue ex vivo

BACKGROUND: HIV-1 Nef critically contributes to AIDS in part by augmenting virus titers in infected individuals. Analyzing which of Nef's activities contribute to HIV pathogenesis has been hampered by the lack of a cell culture model in which Nef exerts pronounced effects on HIV replication. Th...

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Hlavní autoři: Homann, Stefanie, Tibroni, Nadine, Baumann, Ingo, Sertel, Serkan, Keppler, Oliver T, Fackler, Oliver T
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630989/
https://ncbi.nlm.nih.gov/pubmed/19146681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-6
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