CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4(+) T-Cell Depletion in Human Lymphoid Tissue Ex Vivo

The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important virulence factor. Nef has several functions, including down-modulation of CD4 and class I major histocompatibility complex cell surface expression, enhancement of virion infectivity, and stimulation of viral replication in p...

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Detalhes bibliográficos
Main Authors: Glushakova, Svetlana, Münch, Jan, Carl, Silke, Greenough, Thomas C., Sullivan, John L., Margolis, Leonid, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114585/
https://ncbi.nlm.nih.gov/pubmed/11581379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10113-10117.2001
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