Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

Foxp3 + T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or “secondary” modulation, e.g. using anti-CTLA-4 monoclonal antibody. Our ongoing studies of...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Wang, Liqing, Kumar, Suresh, Dahiya, Satinder, Wang, Feng, Wu, Jian, Newick, Kheng, Han, Rongxiang, Samanta, Arabinda, Beier, Ulf H., Akimova, Tatiana, Bhatti, Tricia R., Nicholson, Benjamin, Kodrasov, Mathew P., Agarwal, Saket, Sterner, David E., Gu, Wei, Weinstock, Joseph, Butt, Tauseef R., Albelda, Steven M., Hancock, Wayne W.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264272/
https://ncbi.nlm.nih.gov/pubmed/27769803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.018
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