Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

Foxp3 + T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or “secondary” modulation, e.g. using anti-CTLA-4 monoclonal antibody. Our ongoing studies of...

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Udgivet i:EBioMedicine
Main Authors: Wang, Liqing, Kumar, Suresh, Dahiya, Satinder, Wang, Feng, Wu, Jian, Newick, Kheng, Han, Rongxiang, Samanta, Arabinda, Beier, Ulf H., Akimova, Tatiana, Bhatti, Tricia R., Nicholson, Benjamin, Kodrasov, Mathew P., Agarwal, Saket, Sterner, David E., Gu, Wei, Weinstock, Joseph, Butt, Tauseef R., Albelda, Steven M., Hancock, Wayne W.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264272/
https://ncbi.nlm.nih.gov/pubmed/27769803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.018
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