Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome

Apert syndrome (AS) is a common genetic syndrome in humans characterized with craniosynostosis. Apert patients and mouse models showed abnormalities in sutures, cranial base and brain, that may all be involved in the pathogenesis of skull malformation of Apert syndrome. To distinguish the differenti...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Luo, Fengtao, Xie, Yangli, Xu, Wei, Huang, Junlan, Zhou, Siru, Wang, Zuqiang, Luo, Xiaoqing, Liu, Mi, Chen, Lin, Du, Xiaolan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264259/
https://ncbi.nlm.nih.gov/pubmed/28123344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.16287
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