Dynamic morphological changes in the skulls of mice mimicking human Apert syndrome resulting from gain-of-function mutation of FGFR2 (P253R)

Apert syndrome is caused mainly by gain-of-function mutations of fibroblast growth factor receptor 2. We have generated a mouse model (Fgfr2(+/P253R)) mimicking human Apert syndrome resulting from fibroblast growth factor receptor 2 Pro253Arg mutation using the knock-in approach. This mouse model in...

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Detalhes bibliográficos
Main Authors: Du, Xiaolan, Weng, Tujun, Sun, Qidi, Su, Nan, Chen, Zhi, Qi, Huabing, Jin, Ming, Yin, Liangjun, He, Qifen, Chen, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913019/
https://ncbi.nlm.nih.gov/pubmed/20557404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7580.2010.01248.x
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