Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clini...

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Vydáno v:Cell Rep
Hlavní autoři: Burikhanov, Ravshan, Hebbar, Nikhil, Noothi, Sunil K., Shukla, Nidhi, Sledziona, James, Araujo, Nathália, Kudrimoti, Meghana, Wang, Qing Jun, Watt, David S., Welch, Danny R., Maranchie, Jodi, Harada, Akihiro, Rangnekar, Vivek M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264245/
https://ncbi.nlm.nih.gov/pubmed/28076793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.051
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