Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

C-reactive protein (CRP) concentrations rise in response to tissue injury or infection. Circulating pentameric CRP (pCRP) localizes to damaged tissue where it leads to complement activation and further tissue damage. In-depth knowledge of the pCRP activation mechanism is essential to develop therape...

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Publicado no:Nat Commun
Main Authors: Braig, David, Nero, Tracy L., Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R., Morton, Craig J., Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A., Mellett, Natalie A., Miles, Luke A., Du, Xiao-Jun, Meikle, Peter J., Huber-Lang, Markus, Stark, G. Björn, Parker, Michael W., Peter, Karlheinz, Eisenhardt, Steffen U.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264208/
https://ncbi.nlm.nih.gov/pubmed/28112148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14188
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