A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

INTRODUCTION: C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pC...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Thiele, Jan R., Zeller, Johannes, Kiefer, Jurij, Braig, David, Kreuzaler, Sheena, Lenz, Yvonne, Potempa, Lawrence A., Grahammer, Florian, Huber, Tobias B., Huber-Lang, M., Bannasch, Holger, Stark, G. Björn, Peter, Karlheinz, Eisenhardt, Steffen U.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911593/
https://ncbi.nlm.nih.gov/pubmed/29713320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00675
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