Targeting EP4 downstream c‐Jun through ERK1/2‐mediated reduction of DNMT1 reveals novel mechanism of solamargine‐inhibited growth of lung cancer cells

Lung cancer is the most common cancer and the leading cause of cancer deaths worldwide. We previously showed that solamargine, one natural phytochemicals from traditional plants, inhibited the growth of lung cancer cells through inhibition of prostaglandin E2 (PGE (2)) receptor EP4. However, the pot...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Chen, Yuqing, Tang, Qing, Xiao, Qian, Yang, LiJun, Hann, Swei S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264151/
https://ncbi.nlm.nih.gov/pubmed/27620163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12958
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