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Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells

BACKGROUND: Lung cancer is the most common cause of cancer-related deaths worldwide. Natural phytochemicals from traditional medicinal plants such as solamargine have been shown to have anticancer properties. The prostaglandin E2 receptor EP4 is highly expressed in human cancer, however, the functio...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Chen, YuQing, Tang, Qing, Wu, JingJing, Zheng, Fang, Yang, LiJun, Hann, Swei Sunny
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687355/
https://ncbi.nlm.nih.gov/pubmed/26689593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0272-0
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