Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells

BACKGROUND: Lung cancer is the most common cause of cancer-related deaths worldwide. Natural phytochemicals from traditional medicinal plants such as solamargine have been shown to have anticancer properties. The prostaglandin E2 receptor EP4 is highly expressed in human cancer, however, the functio...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Chen, YuQing, Tang, Qing, Wu, JingJing, Zheng, Fang, Yang, LiJun, Hann, Swei Sunny
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687355/
https://ncbi.nlm.nih.gov/pubmed/26689593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0272-0
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