A Modification-Specific Peptide-Based Immunization Approach Using CRM197 Carrier Protein: Development of a Selective Vaccine Against Pyroglutamate Aβ Peptides

Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models, but adverse effects have hampered its clinical evaluation. The first anti-A...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Vingtdeux, Valérie, Zhao, Haitian, Chandakkar, Pallavi, Acker, Christopher M, Davies, Peter, Marambaud, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263057/
https://ncbi.nlm.nih.gov/pubmed/27900387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00218
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