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A Modification-Specific Peptide-Based Immunization Approach Using CRM197 Carrier Protein: Development of a Selective Vaccine Against Pyroglutamate Aβ Peptides
Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models, but adverse effects have hampered its clinical evaluation. The first anti-A...
में बचाया:
| में प्रकाशित: | Mol Med |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Feinstein Institute for Medical Research
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5263057/ https://ncbi.nlm.nih.gov/pubmed/27900387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00218 |
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