Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Kinsella, B T, Erdman, R A, Maltese, W A
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1991
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.20.8934
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