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Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.

ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e., Cys-Ali-Ali-Ser/Met (where Ali represents an aliphatic residue). In other low molecular mass GTP-binding proteins, cysteines are modified by 20-...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kinsella, B T, Erdman, R A, Maltese, W A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924354/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.20.8934
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