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Molecular dynamics simulations of spontaneous fibril formation by random-coil peptides

Assembly of normally soluble proteins into amyloid fibrils is a cause or associated symptom of numerous human disorders, including Alzheimer's and the prion diseases. We report molecular-level simulation of spontaneous fibril formation. Systems containing 12-96 model polyalanine peptides form f...

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Detaylı Bibliyografya
Asıl Yazarlar: Nguyen, Hung D., Hall, Carol K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC526199/
https://ncbi.nlm.nih.gov/pubmed/15534217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407273101
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