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Molecular dynamics simulations of spontaneous fibril formation by random-coil peptides
Assembly of normally soluble proteins into amyloid fibrils is a cause or associated symptom of numerous human disorders, including Alzheimer's and the prion diseases. We report molecular-level simulation of spontaneous fibril formation. Systems containing 12-96 model polyalanine peptides form f...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC526199/ https://ncbi.nlm.nih.gov/pubmed/15534217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407273101 |
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