Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms

Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which releases iron from duodenal enterocytes, hepatocytes...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Enculescu, Mihaela, Metzendorf, Christoph, Sparla, Richard, Hahnel, Maximilian, Bode, Johannes, Muckenthaler, Martina U., Legewie, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261815/
https://ncbi.nlm.nih.gov/pubmed/28068331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005322
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