Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

In inflammation, extensive cell death may occur, which results in the release of chromatin components into the extracellular environment. Individually, the purified chromatin components double stranded (ds)DNA and histones have been demonstrated, both in vitro and in vivo, to display various immunos...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Marsman, Gerben, Zeerleder, Sacha, Luken, Brenda M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261016/
https://ncbi.nlm.nih.gov/pubmed/27929534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.410
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